The icon is depicting three Orthodox Saints: St Eudocia, St Nicholas, and St Anastasia of Sirmium.
Saint Eudocia (Eudokia) was a Samarian woman who lived in Heliopolis of Phoenicia (present-day Baalbek, Lebanon). She was a very beautiful pagan and garnered her wealth by attracting wealthy lovers. Eudokia learned about Christianity from a monk by the name of Germanos and asked him if she, too, could be saved from Judgment. Germanos instructed her to remain alone in her chamber for one week, fasting and praying. Eudokia followed his instructions, and at the end of the week, she had a vision about the Archangel Michael that assured her of Christ's love for all people. At age 30, Eudokia commissioned the building of a monastery near Heliopolis and dispensed much of her wealth in various charitable projects. She rejected all of her suitors, and when one persistent suitor named Philostratus was struck down because of his persistence, Eudokia prayed for him until he recovered and then converted to Christianity. Eudokia persuaded many pagans to convert to Christianity and, by her actions, angered Roman officials who had her beheaded in 107 AD.
Saint Nicholas of Myra (270 - 343), was a historic 4th-century Saint and Greek Bishop of Myra. Because of the many miracles attributed to his intercession, he is also known as Nikolas the Wonderworker. He had a reputation for secret gift-giving, such as putting coins in the shoes of those who left them out for him, and thus became the model for Santa Claus. His reputation evolved among the faithful, as was common for early Christian saints.
Saint Martyress Anastasia of Sirmium (Saint Anastasia Stritzoula) is a Christian saint and martyr who died at Sirmium in the Roman province of Pannonia Secunda. In the Orthodox Church, she is venerated as St. Anastasia the Pharmakolytria, i.e. "Deliverer from Potions" or "Anastasia the Healer". She is often given the epithets, "Deliverer from Bonds" and "Deliverer from Potions", because her intercessions are credited with the protection of the faithful from poison and other harmful substances.
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