Our Lady of the Sign is one of the most beloved Russian miracleworking icons of Theotokos. The icon depicts Her during the Annunciation at the moment of saying, "May it be done to me according to your word." (Luke 1:38). The Virgin Mary is depicted frontally half-length, with her hands raised in praying position and the Child Jesus within a round aureole upon her breast representing him at the moment of his conception. The term Virgin of the Sign is a reference to the prophecy of Isaiah 7:14: "Therefore the Lord himself shall give you a sign; Behold, a virgin shall conceive, and bear a son, and shall call his name Immanuel.
The icon has a depiction of four female Martyr saints on borders: St. Martyr Catherine, St. Martyr Barbara, St. Venerable Martyr Anysia, and St. Martyr Paraskevi (Friday).
The icon dates to the 17th century, while the silver revetment cover is dating to 1900-1908, the maker's mark MC for Maria Sokolova in Moscow.